Theresa Knott – Mikroskop RWTH Aachen – Bio‑1

Unit of Plant Molecular Cell Biology – Original Articles

Original articles (in reverse chronological order)

  • Munch D., Rubiato H., Kwaaitaal M., Reinstädler R., Panstruga R., and Nielsen M. 2026. Distinct membrane trafficking pathways defined by the requirement for GNOM or BIG1 to BIG4 mediate pre‑invasive immunity towards filamentous fungal pathogens. New Phytologist 250: 472‑586. PubMed‑Abstract
  • Loos A., Doykova E., Qian J., Kümmel F., Ibrahim H., Kiss L., Panstruga R., and Kusch S. 2025. Saprotrophic Arachnopeziza species as new resources to study the obligate biotrophic lifestyle of powdery mildew fungi. Molecular Ecology Resources 25: e70045. PubMed‑Abstract
  • Qian J., Xue H., Ou S., Mann L., Storer J., Fürtauer L., Heitkam T., Wildermuth M., Kusch S., and Panstruga R. 2025. TEtrimmer: A tool to automate the manual curation of transposable elements. Nature Communications 16: 8429. PubMed‑Abstract
  • Sabelleck B., Freh M., Lammertz M., Browatzki J., Vllaho A.-M., Pislewska‑Bednarek M., Bednarek P., and Panstruga R. 2025. Thiamine is a vitamin for plant‑pathogenic powdery mildew fungi. iScience 28: 113123. PubMed‑Abstract
  • Spiller L., Zhang L., Gerra S., Stoppe C., Scheiermann P., Calandra T., Lolis E., Panstruga R., Bernhagen J., and Hoffmann A. 2025. Synergistic enhancement of MIF‑mediated acute lung injury by its plant ortholog MDL1 in vivo. FASEB Journal 39: e70489. PubMed‑Abstract
  • Sabelleck B., Deb S., Levecque S. C. J., Freh M., Reinstädler A., Spanu P. D., Thordal‑Christensen H., and Panstruga R. 2025. A powdery mildew core effector protein targets the host endosome tethering complexes HOPS and CORVET in barley. Plant Physiology 197: kiaf067. PubMed‑Abstract
  • Ruf A., Thieron H., Nasfi S., Lederer B., Fricke S., Adeshara T., Postma J., Blumenkamp P., Kwon S., Brinkrolf K., Feldbrügge M., Goesmann A., Kehr J., Steinbrenner J., Šečić E., Göhre V., Weiberg A., Kogel K.-H., Panstruga R., and Robatzek S. 2024. Broad‑scale phenotyping in Arabidopsis reveals varied involvement of RNA interference across diverse plant‑microbe interactions. Plant Direct 8: e70017. PubMed‑Abstract
  • Kusch S., Frantzeskakis L., Lassen B. D., Kümmel F., Pesch L., Barsoum M., Walden K. D., and Panstruga R. 2024. A fungal pathogen overcomes mlo‑mediated broad‑spectrum disease resistance by rapid gene loss. New Phytologist 244: 962‑979. PubMed‑Abstract
  • Freh M., Reinstädler A., Neumann K. D., Neumann U., and Panstruga R. 2024. The development of pleiotropic phenotypes in powdery mildew‑resistant barley and Arabidopsis thaliana mlo mutants is linked to nitrogen availability. Plant, Cell & Environment 47: 2362‑2376. PubMed‑Abstract
  • Huebbers J. W., Caldarescu G. A., Kubátova Z, Sabol P., Levecque S. C. J., Kuhn H., Kulich I., Reinstädler A., Büttgen K., Manga‑Robles A., Mélida H., Pauly M., Panstruga R.*, and Žárský V.* 2024. Interplay of EXO70 and MLO proteins modulates trichome cell wall composition and powdery mildew susceptibility. Plant Cell 36: 1007‑1035. PubMed‑Abstract
  • Spiller L., Manjula R., Leissing F., Basquin J., Conti E., Bourilhon P., Sinitski D., Brandhofer M., Levecque S., Gerra S., Sabelleck B., Zhang L., Feederle R., Flatley A., Hoffmann A., Panstruga R.*, Bernhagen J.*, and Lolis E.* 2023. Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells. Science Signaling 16: eadg2621. PubMed‑Abstract
  • Qian J., Ibrahim H. M. M., Erz M., Kümmel F., Panstruga R., and Kusch S. 2023. Long noncoding RNAs emerge from transposon‑derived antisense sequences and may contribute to infection stage‑specific transposon regulation in a fungal phytopathogen. Mobile DNA 14: 17. PubMed‑Abstract
  • von Bongartz K., Sabelleck B., Forero A. B., Kuhn H., Leissing F., and Panstruga R. 2023. Comprehensive comparative assessment of the Arabidopsis thaliana MLO2‑CALMODULIN2 interaction by various in‑vitro and in‑vivo protein‑protein interaction assays. Biochemical Journal 480: 1615‑1638. PubMed‑Abstract
  • Kusch S., Singh M., Thieron H., Spanu P. D., and Panstruga R. 2023. Site‑specific analysis reveals candidate cross‑kingdom small RNAs, tRNA and rRNA fragments, and signs of fungal RNA phasing in the barley‑powdery mildew interaction. Molecular Plant Pathology 24: 570‑587. PubMed‑Abstract
  • Huebbers J. W., Mantz M., Panstruga R., and Huesgen P. 2023. Proteomics dataset on detached and purified Arabidopsis thaliana rosette leaf trichomes. Data in Brief 46: 108897. PubMed‑Abstract
  • Huebbers J. W., Büttgen K., and Panstruga R. 2022. Efficient isolation and purification of high‑quality Arabidopsis thaliana trichomes. Current Protocols 9: e541. PubMed‑Abstract
  • Vaghefi N., Kusch S., Németh M. Z., Seress D., Braun U., Takamatsu S., Panstruga R., and Kiss L. 2022. Beyond nuclear ribosomal DNA sequences: Evolution, taxonomy, and closest known saprobic relatives of powdery mildew fungi (Erysiphaceae) inferred from their first comprehensive genome‑scale phylogenetic analyses. Frontiers in Microbiology 13: 903024. PubMed‑Abstract
  • Acevedo‑Garcia J., Walden K., Leissing F., Baumgarten K., Drwiega K., Kwaaitaal M., Reinstädler A., Freh M., Dong X., James G. V., Baus L. C., Mascher M., Stein N., Schneeberger K., Brocke‑Ahmadinejad N., Kollmar M., Schulze‑Lefert P., and Panstruga R. 2022. Barley Ror1 encodes a class XI myosin required for mlo‑based broad‑spectrum resistance to the fungal powdery mildew pathogen. Plant Journal 112: 84‑103. PubMed‑Abstract
  • Huebbers J. W., Büttgen K., Leissing F., Mantz M., Pauly M., Huesgen P. F., and Panstruga R. 2022. An advanced method for the release, enrichment and purification of high‑quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome. Plant Methods 18: 12. PubMed‑Abstract
  • Kusch S., Vaghefi N., Takamatsu S., Liu S.-Y., Németh M. Z., Seress D., Frantzeskakis L., Chiu P.-E., Panstruga R., and Kiss L. 2022. First draft genome assemblies of Pleochaeta shiraiana and Phyllactinia moricola, two tree‑parasitic powdery mildew fungi with hemiendophytic mycelia. Phytopathology 112: 961‑967. PubMed‑Abstract
  • Durán P., Reinstädler A., Rajakrut A. L., Hashimoto M., Garrido‑Oter R., Schulze‑Lefert P., and Panstruga R. 2021. A fungal powdery mildew pathogen induces extensive local and marginal systemic changes in the Arabidopsis thaliana microbiota. Environmental Microbiology 23: 6292‑6308. PubMed‑Abstract
  • Gruner K., Leissing F., Sinitski D., Thieron H., Axstmann C, Baumgarten K., Reinstädler A., Winkler P., Altmann M., Flatley A., Jaounnet M., Zienkiewicz K., Feussner I., Keller H., Coustau C., Falter‑Braun P., Feederle R., Bernhagen J., and Panstruga R. 2021. Chemokine‑like MDL proteins modulate flowering time and innate immunity in plants. Journal of Biological Chemistry 296: 100611. PubMed‑Abstract
  • Pereira Mendes M., Hickman R., Van Verk M. C., Nieuwendijk N. M., Reinstädler A., Panstruga R., Pieterse C. M. J., and Van Wees S. C. M. 2021. A family of pathogen‑induced cysteine‑rich transmembrane proteins involved in plant disease resistance. Planta 253: 102. PubMed‑Abstract
  • Gruner K., Esser T., Acevedo‑Garcia J., Freh M., Habig M., Strugala R., Stukenbrock E., Schaffrath U., and Panstruga R. 2020. Evidence for allele‑specific levels of enhanced susceptibility of wheat mlo mutants to the hemibiotrophic fungal pathogen Magnaporthe oryzae pv. Triticum. Genes 11: 517. PubMed‑Abstract
  • Barsoum M., Kusch S., Frantzeskakis L., Schaffrath U., and Panstruga R. 2020. UV mutagenesis coupled with next‑generation sequencing as a method for functional interrogation of powdery mildew genomes. Molecular Plant‑Microbe Interactions 33: 1008‑1021. PubMed‑Abstract
  • Kusch S., Németh M. Z., Vaghefi N., Ibrahim H. M. M., Panstruga R., and Kiss L. 2020. A short‑read genome assembly resource for Leveillula taurica causing powdery mildew disease of sweet pepper (Capsicum annuum). Molecular Plant‑Microbe Interactions 33: 782‑786. PubMed‑Abstract
  • Sinitski D., Gruner K., Brandhofer M., Kontos C., Winkler P., Reinstädler A., Bourilhon P., Xiao Z., Cool R., Kapurniotu A., Dekker F. J., Panstruga R., and Bernhagen J. 2020. Cross‑kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs. Journal of Biological Chemistry 295: 850‑867. PubMed‑Abstract
  • Wu H., Zhang W., Schuster M., Moch M., Windoffer R., Steinberg G., Staiger C. J., and Panstruga R. 2020. Alloxan disintegrates the plant cytoskeleton and suppresses mlo‑mediated powdery mildew resistance. Plant & Cell Physiology 61: 505‑518. PubMed‑Abstract
  • Michelet C., Danchin E. G. J., Jaouannet M., Bernhagen J., Panstruga R., Kogel K.-H., Keller H., and Coustau C. 2019. Cross‑kingdom analysis of diversity, evolutionary history, and site selection within the eukaryotic macrophage migration inhibitory factor superfamily. Genes 10: 740. PubMed‑Abstract
  • Frantzeskakis L., Németh M., Barsoum M., Kusch S., Kiss L., Takamatsu S., and Panstruga R. 2019. The Parauncinula polyspora draft genome provides insights in patterns of gene erosion and genome expansion in powdery mildew fungi. mBio 10: e01692‑19. PubMed‑Abstract
  • Kusch S., Thiery S., Reinstädler A., Gruner K., Zienkiewicz K., Feussner I., and Panstruga R. 2019. Arabidopsis mlo3 mutant plants exhibit spontaneous callose deposition and signs of early leaf senescence. Plant Molecular Biology 101: 21‑40. PubMed‑Abstract
  • Smigielski L., Laubach E.-M., Pesch L., Glock J. M. L., Albrecht F., Slusarenko A., Panstruga R., and Kuhn H. 2019. Nodulation induces systemic resistance of Medicago truncatula and Pisum sativum against Erysiphe pisi and primes for powdery mildew‑triggered salicylic acid accumulation. Molecular Plant‑Microbe Interactions 32: 1243‑1255. PubMed‑Abstract
  • Saur I. M. L., Bauer S., Kracher B., Lu X., Frantzeskakis L., Müller M. C., Sabelleck B., Kümmel F., Panstruga R., Maekawa T., and Schulze‑Lefert P. 2019. Multiple pairs of allelic MLA immune receptor‑powdery mildew AVRA effectors argue for a direct recognition mechanism. eLife 8: e44471. PubMed‑Abstract
  • Pennington H. G., Jones R., Kwon S., Bonciani G., Thieron H., Chandler T., Luong P., Morgan S., Przydacz M., Bozkurt T. O., Bowden S., Craze M., Wallington E., Garnett J., Kwaaitaal M., Panstruga R.*, Cota E.*, and Spanu P. D.* 2019. The fungal ribonuclease‑like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA. PLoS Pathogens 15: e1007620. PubMed‑Abstract
  • Lammertz M., Kuhn H., Pfeilmeier S., Malone J., Zipfel C., Kwaaitaal M., Lin N.-C., Kvitko B. H., and Panstruga R. 2019. Widely‑conserved attenuation of plant MAMP‑induced calcium influx by bacteria depends on multiple virulence factors and may involve desensitization of host pattern recognition receptors. Molecular Plant‑Microbe Interactions 32: 608‑621. PubMed‑Abstract
  • Kusch S., Frantzeskakis L., Thieron H., and Panstruga R. 2018. Small RNAs from cereal powdery mildew pathogens may target host plant genes. Fungal Biology 122: 1055‑1063. PubMed‑Abstract
  • Frantzeskakis L., Kracher B., Kusch S., Yoshikawa‑Maekawa M., Bauer S., Pedersen C., Spanu P. D., Maekawa T., Schulze‑Lefert P., and Panstruga R. 2018. Signatures of host specialization and a recent transposable element burst in the dynamic one‑speed genome of the fungal barley powdery mildew pathogen. BMC Genomics 19: 381. PubMed‑Abstract
  • Cui F., Wu H., Safronov O., Zhang P., Kumar R., Kollist H., Salojärvi J., Panstruga R., and Overmeyer K. 2018. Arabidopsis MLO2 is a negative regulator of sensitivity to extracellular reactive oxygen species. Plant Cell and Environment 41: 782‑796. PubMed‑Abstract
  • Wu H., Kwaaitaal M., Strugala R., Schaffrath U., Bednarek P., and Panstruga R. 2017. Chemical suppressors of mlo‑mediated powdery mildew resistance. Bioscience Reports 37: BSR20171389. PubMed‑Abstract
  • Acevedo‑Garcia J., Gruner K., Reinstädler A., Kemen A., Kemen E., Cao L., Takken F. W. L., Reitz M. U., Schfer P., O’Connell R. J., Kusch S., Kuhn H., and Panstruga R. 2017. The powdery mildew‑resistant Arabidopsis mlo2 mlo6 mlo12 triple mutant displays altered infection phenotypes with diverse types of phytopathogens. Scientific Reports 7: 9319. PubMed‑Abstract
  • Kuhn H., Lorek J., Kwaaitaal M., Consonni C., Becker K., Micali C., Ver Loren van Themaat E., Bednarek P., Raymaakers T. M., Appiano M., Bai Y., Meldau D., Baum S., Conrath C., Feussner I., and Panstruga R. 2017. Key components of different plant defense pathways are dispensable for powdery mildew resistance of the Arabidopsis mlo2 mlo6 mlo12 triple mutant. Frontiers in Plant Science 8: 1006. PubMed‑Abstract
  • Acevedo‑Garcia J., Spencer D., Thieron H., Reinstädler A., Hammond‑Kosack K., Phillips A. L., and Panstruga R. 2017. mlo‑based powdery mildew resistance in hexaploid bread wheat generated by a non‑transgenic TILLING approach. Plant Biotechnology Journal 15: 367‑378. PubMed‑Abstract
  • Budhagatapalli N., Schedel S., Gurushidze M., Pencs S., Hiekel S., Rutten T., Kusch S., Morbitzer R., Lahaye T., Panstruga R., Kumlehn J., and Hensel G. 2016. A simple test for the cleavage activity of customized endonucleases in plants. Plant Methods 9: 18. PubMed‑Abstract
  • Kusch S., Pesch L., and Panstruga R. 2016. Comprehensive phylogenetic analysis sheds light on the diversity and origin of the MLO family of integral membrane proteins. Genome Biology & Evolution 8: 878‑895. PubMed‑Abstract
  • Panstruga R.*, Baumgarten K., and Bernhagen J. 2015. Phylogeny and evolution of plant macrophage migration inhibitory factor/D‑dopachrome tautomerase‑like proteins. BMC Evolutionary Biology 15: 64. PubMed‑Abstract
  • Kusch S., Ahmadinejad N., Panstruga R., and Kuhn H. 2014. In silico analysis of the core signaling proteome from the barley powdery mildew pathogen (Blumeria graminis f.sp. hordei). BMC Genomics 15: 843. PubMed‑Abstract
  • Maintz J., Cavdar M., Tamborski J., Kwaaitaal M., Huisman R., Meesters C., Kombrink E., and Panstruga R. 2014. Comparative analysis of MAMP‑induced calcium influx in Arabidopsis seedlings and protoplasts. Plant & Cell Physiology 55: 1813‑1825. PubMed‑Abstract
  • Weßling R., Epple P. E., Altmann S., He Y., Yang L., Henz S. R., McDonald N., Wiley K., Bader K. C., Gläser C., Mukhtar M. S., Haigis S., Ghamasari L., Stephens A. E., Ecker J. R., Vidal M., Jones J. D. G., Mayer K. F. X., Ver Loren van Themaat E., Weigel D., Schulze‑Lefert P., Dangl J. L., and Panstruga R. 2014. Convergent targeting of a common host protein‑network by pathogen effectors from three kingdoms of life. Cell Host & Microbe 16: 364‑375. PubMed‑Abstract
  • Bolger A., Scossa F., Bolger M. E., Lanz C., Maumus F., Tohge T., Quesneville H., Alseekh S., Sørensen I., Lichtenstein G., Fich E. A., Conte M., Keller H., Schneeberger K., Schwacke R., Ofner I., Vrebalov J., Xu Y., Osorio S., Aflitos S. A., Schijlen E., Jiménez‑Gómez J. M., Ryngajllo M., Kimura S., Kumar R., Koenig D., Headland L. R., Maloof J. N., Sinha N., van Ham R. C. H. J., Lankhorst R. K., Mao L., Vogel A., Arsova B., Panstruga R., Fei Z., Rose J. K. C., Zamir D., Carrari F., Giovannoni J. J., Weigel D., Usadel B., and Fernie A. R. 2014. The genome of the stress‑tolerant wild tomato species Solanum pennellii. Nature Genetics 46: 1034‑1038. PubMed‑Abstract
  • Bidzinski P., Noir S., Shahi S., Reinstädler A., Gratkowska D. M., and Panstruga R. 2014. Physiological characterization and genetic modifiers of aberrant root thigmomorphogenesis in mutants of Arabidopsis thaliana MILDEW LOCUS O genes. Plant Cell & Environment 37: 2738‑2753. PubMed‑Abstract
  • Schmidt S. M., Kuhn H., Micali C., Liller C., Kwaaitaal M., and Panstruga R. 2014. Interaction of a *Blumeria graminis* f.sp. *hordei* effector candidate with a barley ARF‑GAP suggests vesicle trafficking is a fungal pathogenicity target. Molecular Plant Pathology 15: 535‑549. PubMed‑Abstract
  • Acevedo‑Garcia J., Collins N., Ahmadinejad N., Ma L., Houben A., Bednarek P., Benjdia M., Freialdenhoven A., Altmüller J., Nürnberger P., Reinhardt R., Schulze‑Lefert P., and Panstruga R. 2013. Fine mapping and chromosome walking towards the Ror1 locus in barley (Hordeum vulgare L.). Theoretical and Applied Genetics 126: 2969‑2982. PubMed‑Abstract
  • Feechan A., Jermakow A.M., Ivancevic A., Godfrey D., Pak H., Panstruga R., and Dry I.B. 2013. Host cell entry of powdery mildew is correlated with endosomal transport of antagonistically acting VvPEN1 and VvMLO to the papilla. Molecular Plant‑Microbe Interactions 26: 1138‑1150. PubMed‑Abstract
  • Lorek J., Griebel T., Jones A. M., Kuhn H., and Panstruga R. 2013. The role of Arabidopsis heterotrimeric G‑protein subunits in MLO2 function and MAMP‑triggered immunity. Molecular Plant‑Microbe Interactions 26: 991‑1003. PubMed‑Abstract
  • Pedersen C., Ver Loren van Themaat E., McGuffin L. J., Abbott J. C., Burgis T. A., Barton G., Bindschedler L. V., Lu X., Maekawa T., Weßling R., Cramer R., Thordal‑Christensen H., Panstruga R.*, and Spanu P.D.* 2012. Structure and evolution of barley powdery mildew effector candidates. BMC Genomics 13: 694. PubMed‑Abstract (* co‑corresponding authors)
  • Weßling R., and Panstruga R. 2012. Rapid quantification of plant‑powdery mildew interactions by qPCR and conidiospore counts. Plant Methods 8: 35. PubMed‑Abstract
  • Kwaaitaal M., Maintz J., Cavdar M., and Panstruga R. 2012. On the ligand binding profile and desensitization of plant ionotropic glutamate receptor (iGluR)‑like channels functioning in MAMP‑triggered Ca2+ influx. Plant Signaling & Behavior 7: 1373‑1377. PubMed‑Abstract
  • O'Connell R. J., Thon M. R., Hacquard S., Ver Loren van Themaat E., Amyotte S. G., Kleemann J., Torres M. F., Damm U., Buiate E. A., Epstein L., Alkan N., Altmüller J., Alvarado‑Balderrama L., Bauser C. L., Becker C., Birren B. W., Chen Z., Choi J., Crouch J. A., Duvick J. P., Farman M. L., Gan P., Heiman D., Henrissat B., Howard R. J., Kabbage M., Koch C., Kubo Y., Law A. D., Lebrun M. H., Lee Y.-H., Miyara I., Moore N., Neumann U., Panaccione D. G., Panstruga R., Place M., Proctor R. H., Prusky D., Rech G., Reinhardt R., Rollins J. A., Rounsley S., Schardl C. L., Schwartz D. C., Shenoy N., Shirasu K., Sikhakolli U. R., Stüber K., Sukno S. A., Sweigard J. A., Takano Y., Takahara H., Trail F., van der Does H. C., Voll L. M., Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M. B., Schulze‑Lefert P., Ma L.-J., and Vaillancourt L. J. 2012. Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nature Genetics 44: 1060‑1065. PubMed‑Abstract (F1000 factor 8)
  • Jiang K., Frick‑Cheng A., Trusov Y., Delgado‑Cerezo M., Booker F., Botella J., Molina A., Ort D.R., and Jones A M. 2012. Dissecting Arabidopsis Gβ signal transduction on the protein surface. Plant Physiology 159: 975‑983. PubMed‑Abstract
  • Frei di Frey N., Mbengue M., Kwaaitaal M., Nitsch L., Altenbach D., Häweker H., Lonzano‑Duran R., Njo M. F., Beeckman T., Huettel B., Borst J. W., Panstruga R., and Robatzek S. 2012. Plasma membrane calcium ATPases are important components of receptor‑mediated signalling in plant immune responses and development. Plant Physiology 159: 798‑809. PubMed‑Abstract
  • Weßling R., Schmidt S. M., Micali C. O., Knaust F., Reinhardt R., Neumann U., Ver Loren van Themaat E., and Panstruga R. 2012. Transcriptome analysis of enriched Golovinomyces orontii haustoria by deep 454 pyrosequencing. Fungal Genetics & Biology 49: 470‑482. PubMed‑Abstract
  • Klopffleisch K., Phan N., Augustin K., Bayne R. S., Booker K. S., Botella J. R., Carpita N. C., Carr T., Chen J.-G., Cooke T. R., Frick‑Cheng A., Friedman E.J., Fulk B., Hahn M. G., Jiang K., Jorda L., Kruppe L., Liu C., Lorek J., McCann M. C., Molina A., Moriyama E. N., Mukhtar M. S., Mudgil Y., Pattathil S., Schwarz J., Seta S., Tan M., Temp U., Trusov Y., Urano D., Welter B., Yang J., Panstruga R.*, Uhrig J. F.*, and Jones A.M.* 2011. Arabidopsis G‑protein interactome reveals connections to cell‑wall carbohydrates and morphogenesis. Molecular Systems Biology 7: 532. PubMed‑Abstract (* co‑corresponding authors; F1000 factor 8)
  • Kwaaitaal M., Huisman R., Maintz J., Reinstädler A., and Panstruga R. 2011. Ionotropic glutamate receptor (iGluR)‑like channels mediate MAMP‑triggered calcium influx in Arabidopsis thaliana. Biochemical Journal 440: 355‑365. PubMed‑Abstract (most cited paper in Biochem. J. Knowledge Environment)
  • Humphry M., Reinstädler A., Ivanov S., Bisseling T., and Panstruga R. 2011. Durable broad‑spectrum resistance in pea er1 plants is conferred by natural loss‑of‑function mutations in PsMLO1. Molecular Plant Pathology 12: 868‑876. PubMed‑Abstract
  • Micali C., Neumann U., Grunewald D., Panstruga R., and O´Connell R.O. 2011. Biogenesis of a specialized plant‑fungal interface during host cell internalisation of Golovinomyces orontii haustoria. Cellular Microbiology 13: 210‑226. PubMed‑Abstract
  • Spanu P. D., Abbott J. C., Amselem J., Burgis T. A., Soanes D.M., Stüber K., Ver Loren van Themaat E., Brown J. K., Butcher S. A., Gurr S.J., Lebrun M.-H., Ridout C.J., Schulze‑Lefert P., Talbot N.J., Ahmadinejad N., Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V., Both M., Brewer M. T., Cadle‑Davidson L., Cadle‑Davidson M. M., Collemare J., Cramer R., Lopez‑Ruiz F., Frenkel O., Godfrey D., Harriman J., Hoede C., King B. C., Klages S., Kleemann J., Knoll D., Koti P. S., Kreplak J., Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M. G., Montana G., Noir S., O’Connell R. J., Oberhaensli S., Parlange F., Pedersen C., Quesneville H., Reinhardt R., Rott M., Sacristán S., Schmidt S. M., Schön M., Skamnioti P., Sommer H., Stephens A., Takahara H., Thordal‑Christensen H., Vigouroux M., Weßling R., Wicker T., and Panstruga R. 2010. Genome expansion and gene loss in powdery mildew fungi reveal functional trade‑offs in parasitism. Science 330: 1543‑1546. PubMed‑Abstract (F1000 factor 10; highlighted by Dodds 2010)
  • Humphry M., Bednarek P., Kemmerling B., Koh S., Stein M., Goebel U., Stüber K., Piślewska‑Bednarek M., Lorraine A., Schulze‑Lefert P., Somerville S., and Panstruga R. 2010. A regulon conserved in monocot and dicot plants defines a functional module in plant immunity. Proceedings of the National Academy of Sciences U.S.A. 107: 21896‑21901. PubMed‑Abstract
  • Keinath N. F., Kierszniowska S., Lorek J., Bourdais G., Kessler S.A., Asano H., Grossniklaus U., Schulze W., Robatzek S., and Panstruga R. 2010. PAMP‑induced changes in plasma‑membrane compartmentalisation reveal novel components of plant immunity. Journal of Biological Chemistry 285: 39140‑39149. PubMed‑Abstract
  • Kessler S. A., Shimosato‑Asono H., Keinath N. F., Wuest S.E., Ingram G., Panstruga R., and Grossniklaus U. 2010. Conserved molecular components for pollen‑tube reception and fungal invasion. Science 330: 968‑971. PubMed‑Abstract (F1000 factor 10; highlighted by Govers & Angenent 2010)
  • Reinstädler A., Müller J., Czembor J. H., Piffanelli P., and Panstruga R. 2010. Novel induced mlo mutant alleles in combination with site‑directed mutagenesis reveal functionally important domains in the heptahelical barley *Mlo* protein. BMC Plant Biology 10: 31. PubMed‑Abstract
  • Kwaaitaal M., Keinath N.F., Pajonk S., Biskup C., and Panstruga R. 2010. Combined Bimolecular Fluorescence Complementation (BiFC) and Förster Resonance Energy Transfer (FRET) reveals ternary SNARE complex formation in living plant cells. Plant Physiology 152: 1135‑1147. PubMed‑Abstract
  • Consonni C., Bednarek P., Humphry M., Francocci F., Ferrari S., Harzen A., Ver Loren van Themaat E., and Panstruga R. 2010. Tryptophan‑derived metabolites are required for antifungal defence in the *Arabidopsis thaliana* *mlo2* mutant. Plant Physiology 152: 1544‑1561. PubMed‑Abstract
  • Yoshimoto K., Jikumaru Y., Kamiya Y., Kusano M., Consonni C., Panstruga R., Ohsumi Y., and Shirasu K. 2009. Plant autophagy negatively regulates cell death by controlling NPR1‑dependent salicylic‑acid signalling during senescence and innate immune response. Plant Cell 21: 2914‑2927. PubMed‑Abstract
  • Chen Z. Y.*, Noir S.*, Kwaaitaal M., Hartmann H. A., Wu M. J., Mudgil Y., Sukumar P., Muday G., Panstruga R.#, and Jones A. M. J. 2009. Two seven‑transmembrane domain MLO proteins co‑function in root thigmomorphogenesis. Plant Cell 21: 1972‑1991. PubMed‑Abstract (* authors contributed equally; # corresponding author)
  • Bednarek B., Piślewska‑Bednarek M., Svatoš A., Schneider B., Doubský J., Mansourova M., Humphry M., Consonni C., Panstruga R., Sanchez‑Vallet A., Molina A., Lim M., Somerville S., and Schulze‑Lefert P. 2009. A glucosinolate metabolism pathway in living plant cells mediates broad‑spectrum antifungal defence. Science 323: 101‑106. PubMed‑Abstract (F1000 factor 6)
  • Noir S., Colby T., Harzen A., Schmidt J., and Panstruga R. 2009. A proteomic analysis of powdery mildew (*Blumeria graminis* f.sp. *hordei*) conidiospores. Molecular Plant Pathology 10: 223‑236. PubMed‑Abstract
  • Feechan A., Jermakow A., Torregrosa L. L., Panstruga R., and Dry I. I. B. 2008. Identification of grapevine MLO gene candidates involved in susceptibility to powdery mildew. Functional Plant Biology 35: 1255‑1266. PubMed‑Abstract
  • Pajonk S., Kwon C., Clemens N., Panstruga R., and Schulze‑Lefert P. 2008. Activity determinants and functional specialization of Arabidopsis PEN1 syntaxin in innate immunity. Journal of Biological Chemistry 283: 26974‑26984. PubMed‑Abstract
  • Kwon C., Neu C., Pajonk S., Yun H. S., Lipka U., Humphry M. E., Bau S., Straus M., Rampelt H., El Kasmi F., Jürgens G., Parker J., Panstruga R.*, Lipka V.*, and Schulze‑Lefert P.* 2008. Co‑option of a default secretory pathway for plant immune responses. Nature 451: 835‑840. PubMed‑Abstract (* co‑corresponding authors)
  • Göllner K., Schweizer P., Bai Y., and Panstruga R. 2008. Natural genetic resources of Arabidopsis thaliana reveal a high prevalence and unexpected phenotypic plasticity of RPW8‑mediated powdery mildew resistance. New Phytologist 177: 725‑742. PubMed‑Abstract
  • Bai Y., Pavan S., Zheng Z., Zappel N. F., Reinstädler A., Lotti C., De Giovanni C., Ricciardi L., Lindhout P., Visser R., Theres K., and Panstruga R. 2008. Naturally occurring broad‑spectrum powdery mildew resistance in a Central American tomato accession is caused by loss of Mlo function. Molecular Plant‑Microbe Interactions 21: 30‑39. PubMed‑Abstract
  • Freymark G., Diehl T., Miklis M., Romeis T., and Panstruga R. 2007. Antagonistic control of powdery mildew host cell entry by barley calcium‑dependent protein kinases (CDPKs). Molecular Plant‑Microbe Interactions 20: 1213‑1221. PubMed‑Abstract
  • Miklis M., Consonni C., Bhat R. A., Lipka V., Schulze‑Lefert P., and Panstruga R. 2007. Barley MLO modulates actin‑dependent and actin‑independent antifungal defence pathways at the cell periphery. Plant Physiology 144: 1132‑1143. PubMed‑Abstract
  • Consonni C.*, Humphry M. E.*, Hartmann H. A., Livaja M., Durner J., Westphal L., Vogel J., Lipka V., Schulze‑Lefert P., Somerville S. C., and Panstruga R. 2006. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nature Genetics 38: 716‑720. PubMed‑Abstract (* authors contributed equally)
  • Chen Z., Hartmann H. A., Wu M.-J., Friedman E. J., Chen J.-G., Pulley M., Schulze‑Lefert P., Panstruga R., and Jones A. M. 2006. Expression analysis of the AtMLO gene family encoding plant‑specific seven‑transmembrane domain proteins. Plant Molecular Biology 60: 583‑597. PubMed‑Abstract
  • Noir S., Bräutigam A., Colby T., & Panstruga R. 2005. A reference map of the *Arabidopsis thaliana* mature pollen proteome. Biochemical and Biophysical Research Communications 337: 1257‑1266. PubMed‑Abstract
  • Panstruga R. 2005. Discovery of novel conserved peptide domains by ortholog comparison within plant multi‑protein families. Plant Molecular Biology 59: 485‑500. PubMed‑Abstract
  • Van Damme M., Andel A., Huibers R. P., Panstruga R., Weisbeek P. J., & van den Ackerveken G. 2005. Identification of *Arabidopsis* loci required for susceptibility to the downy mildew pathogen *Hyaloperonospora parasitica*. Molecular Plant‑Microbe Interactions 18: 583‑592. PubMed‑Abstract
  • Panstruga R., Molina‑Cano J., Reinstädler A., & Müller J. 2005. Molecular characterisation of *mlo* mutants in North American two‑ and six‑rowed malting barley cultivars. Molecular Plant Pathology 6: 315‑320. PubMed‑Abstract
  • Bhat R. A., Miklis M., Schmelzer E., Schulze‑Lefert P., & Panstruga R. 2005. Recruitment and interaction dynamics of plant penetration‑resistance components in a plasma membrane micro‑domain. Proceedings of the National Academy of Sciences U.S.A. 102: 3135‑3140. PubMed‑Abstract
  • Müller J., Piffanelli P., Devoto A., Miklis M., Elliott C., Ortmann B., Schulze‑Lefert P., & Panstruga R. 2005. Conserved ERAD‑like quality control of a plant polytopic membrane protein. Plant Cell 17: 149‑163. PubMed‑Abstract
  • Elliott C.*, Müller J.*, Miklis M., Bhat R. A., Schulze‑Lefert P., & Panstruga R. 2005. Conserved extracellular cysteines and cytoplasmic loop‑loop interplay are required for functionality of the heptahelical MLO protein. Biochemical Journal 385: 243‑254. PubMed‑Abstract
  • Piffanelli P., Ramsay L.*, Waugh R., Benabdelmouna A., D´Hont A., Hinze K., Jørgensen H.J., Schulze‑Lefert P., & Panstruga R. 2004. A barley cultivation‑associated polymorphism conveys resistance to powdery mildew. Nature 430: 887‑891. PubMed‑Abstract
  • Jacobs A. K.*, Lipka V.*, Burton R. A., Panstruga R., Strizhov N., Schulze‑Lefert P., & Fincher G. B. 2003. An *Arabidopsis thaliana* callose synthase, *GSL5*, is required for wound and papillary callose formation. Plant Cell 15: 2503‑2513. PubMed‑Abstract
  • Panstruga R., Kim M. C., Cho M. J., & Schulze‑Lefert P. 2003. Testing the efficiency of dsRNAi constructs in vitro: a transient expression assay based on two fluorescent proteins. Molecular Biology Reports 30: 135‑140. PubMed‑Abstract
  • Devoto A., Hartmann H. A., Piffanelli P., Elliott C., Simmons C., Taramino G., Goh C.-S., Cohen F. E., Emerson B. C., Schulze‑Lefert P., & Panstruga R. 2003. Molecular phylogeny and evolution of the plant‑specific seven transmembrane MLO family. Journal of Molecular Evolution 56: 77‑88. PubMed‑Abstract
  • Elliott C., Zhou F., Spielmeyer W., Panstruga R., & Schulze‑Lefert P. 2002. Functional conservation of wheat and rice *Mlo* orthologs in plant defence modulation to powdery mildew. Molecular Plant‑Microbe Interactions 15: 1069‑1077. PubMed‑Abstract
  • Piffanelli P., Zhou F., Casais C., Orme J., Schaffrath U., Collins N., Panstruga R., & Schulze‑Lefert P. 2002. The barley MLO modulator of defence and cell death is responsive to biotic and abiotic stress stimuli. Plant Physiology 129: 1076‑1085. PubMed‑Abstract
  • Kim M. C.*, Panstruga R.*, Elliott C., Müller J., Devoto A., Yoon H. W., Park H., Cho M. J., & Schulze‑Lefert P. 2002. Calmodulin interacts with MLO to regulate defence against mildew in barley. Nature 416: 447‑450. PubMed‑Abstract
  • Devoto A., Piffanelli P., Nilsson I., Wallin E., Panstruga R., von Heijne G., & Schulze‑Lefert P. 1999. Topology, subcellular localization, and sequence diversity of the Mlo family in plants. Journal of Biological Chemistry 274: 34993‑35004. PubMed‑Abstract
  • Panstruga R., Büschges R., Piffanelli P., & Schulze‑Lefert P. 1998. A contiguous 60 kb genomic stretch from barley reveals molecular evidence for gene islands in a monocot genome. Nucleic Acids Research 26: 1056‑1062. PubMed‑Abstract
  • Büschges R.*, Hollricher K.* , Panstruga R.*, Simons G.*, Wolter M., Frijters A., van Daelen R., van der Lee T., Diergaarde P., Groenendijk J., Töpsch S., Vos P., Salamini F., & Schulze‑Lefert P. 1997. The barley *Mlo* gene: A novel control element of plant pathogen resistance. Cell 88: 695‑705. PubMed‑Abstract
  • Panstruga R., Hippe‑Sanwald S., Yeon‑Kyeong L., Lataster M., Lipka V., Fischer R., Liao Y. C., Häusler R. E., Kreuzaler F., Hirsch H.-J. 1997. Expression and chloroplast‑targeting of active phosphoenolpyruvate synthetase from Escherichia coli in Solanum tuberosum. Plant Science 127: 191‑205.
  • Gehlen J., Panstruga R., Smets H., Merkelbach S., Kleines M., Porsch P., Fladung M., Becker I., Rademacher T., Häusler R. E., & Hirsch H.-J. 1996. Effects of altered phosphoenolpyruvate carboxylase activities on transgenic C3 plant *Solanum tuberosum*. Plant Molecular Biology 32: 831‑848. PubMed‑Abstract
  • Panstruga R., Seiler A., Hirsch H.-J., & Kreuzaler F. 1995. Genomic structure of a phosphoenolpyruvate carboxylase gene from potato (*Solanum tuberosum*) (Accession No. X90986) (PGR95‑086). Plant Physiology 109: 110.
Last updated: 12.05.2026